Infectious Disease Compendium

Doripenam (Doribax®)

Dosing

CrCl Formula

CrCl > 50: 500 mg iv q 8.

CrCl ≥30 to ≤50: 250 mg iv q 8 hours.

CrCl > 10 to <30: 250 mg iv q 12 hours

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Rants and Screeds

Pearls

There may be better outcomes if given as a 4 hour infusion rather than a one hour infusion (PubMed).

Treatment of choice

Use for

When compared head to head, it was inferior (more deaths) to imipenam and the trial was stopped early.

FDA approved for complicated intra-abdominal infection and complicated urinary tract infections.

Don't use for

Staphylococcus aureus (MRSA), Enterococcus faecium, and Stenotrophomonas maltophilia.

Class

Carbapenem.