Infectious Disease Compendium

Dolutregravir (Review)

CrCl Formula

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Treatment naive or with no resistance mutations: 50 mg qd

Treatment experienced with known or suspected resistance mutations


given with efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, rifampin, other UGT1A/CYP3A inducers 50 mg bid

Important side effects

Insomnia, headache, and, rarely, rash including hypersensitivity reaction

Increases creatinine by inhibiting creatinine tubular secretion but does not effect actual GFR.

Important drug interactions

Many, serum levels are decreased by efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, rifampin.

Absorption decreased by antacids, laxative and minerals.

Rants and Screeds


Treatment of choice

HIV as part of combination therapy.

Use for

Don't use for


Integrase inhibitor