Infectious Disease Compendium

Dolutregravir (Review)

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

Treatment naive or with no resistance mutations: 50 mg qd

Treatment experienced with known or suspected resistance mutations

OR

given with efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, rifampin, other UGT1A/CYP3A inducers 50 mg bid

Important side effects

Insomnia, headache, and, rarely, rash including hypersensitivity reaction

Increases creatinine by inhibiting creatinine tubular secretion but does not effect actual GFR.

Important drug interactions

Many, serum levels are decreased by efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, rifampin.

Absorption decreased by antacids, laxative and minerals.

Rants and Screeds

Pearls

Treatment of choice

HIV as part of combination therapy.

Use for

Don't use for

Class

Integrase inhibitor