Infectious Disease Compendium

Dirithromycin (Dynabac®)

Dosing

CrCl Formula

CrCl > 80: 500 mg po q 24.

CrCl 80-50: no change.

CrCl 50-10: no change.

CrCl < 10: no change.

Hemodialysis:

Peritoneal dialysis:

Important side effects

GI.

Important drug interactions

Cyclosporine, digoxin, dofetilide, ergot derivatives, fentanyl, pimozide.

Rants and Screeds

Pearls

Treatment of choice

Use for

Nothing. It is less active against everything compared to erythromycin. So use erythromycin instead. Bronchitis, Cellulitis, COPD exacerbation, Pharyngitis, Pneumonia- community acquired, tonsillitis.

Don't use for

Class

Macrolide.