Infectious Disease Compendium

Didanosine (Videx®)

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/tables.

CrCl > 80: >60 kg or more 200 mg in tablet form or 250 mg of the powder formulation, po q 12 h.< 60 kg, 125 mg tablet or 167 mg powder po q 12 h.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Pancreatitis and peripheral neuropathy.

Lactic acidosis and hepatomegaly with steatosis and Noncirrhotic portal hypertension

Important drug interactions

Allopurinol, amprenavir, antacids, atazanavir, atevirdine, cinoxacin, ciprofloxacin, delavirdine, enoxacin, ganciclovir, gemifloxacin, grepafloxacin, hydroxyurea, indinavir, itraconazole, ketoconazole, levofloxacin, lomefloxacin, methadone, moxifloxacin, naladixic acid, nelfinavir, ofloxacin, ribavirin, ritonavir, stavudine, tenofovir, zalcitabine.

Rants and Screeds

Pearls

Treatment of choice

HIV.

Use for

Don't use for

Class

Reverse transcriptase inhibitor.