Infectious Disease Compendium

Delavirdine (Rescriptor®)

Dosing

CrCl Formula

For up-to-date information, go tohttp://hivinsite.ucsf.edu/.

CrCl > 80: 400 mg po tid.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Rash is extremely common; hepatitis; fat redistribution.

Important drug interactions

Antacids, astemizole, atorvastatin, carbamazepine, cimetidine, cisapride, clarithromycin, didanosine, dihydroergotamine, eletriptan, ergoloid mesylates, ergonovine, ergotamine, famotidine, felodipine, fluoxetine, fosamprenavir, fosphenytoin, indinavir, isradipine, ketoconazole, lacidipine, lercanidipine, manidipine, methylergonovine, midazolam, nelfinavir, nicardipine, nifedipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, nizatidine, phenobarbital, phenytoin, quinidine, quinupristin/dalfopristin, ranitidine, rifabutin, rifampin, rifapentine, saquinavir, sildenafil, st john's wort, terfenadine, triazolam, voriconazole, warfarin.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

Non nucleoside reverse transcriptase inhibitor.