Infectious Disease Compendium

Darunavir (Prezista®)

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/.

CrCl > 80: Darunavir must be coadministered with ritonavir

Treatment naive or patients with no mutations associated with resistance to darunavir: Darunavir 800 mg QD + ritonavir 100 mg QD

Treatment experienced with ≥1 mutation associated with resistance to darunavir* Darunavir 600 mg BID + ritonavir 100 mg BID

Important side effects

Important drug interactions

Numerous.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

Protease inhibitor.