Infectious Disease Compendium

Dapsone

Dosing

CrCl Formula

CrCl > 80: 100 po qd.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Amprenavir, cotrimoxazole, probenecid, rifabutin, rifampin, rifapentine, saquinavir, trimethoprim, zidovudine.

Rants and Screeds

Pearls

HLA-B*13:01 is a risk for hypersensitivity. To quote the NEJM (PubMed): HLA-B*13:01 "is present in about 2 to 20% of Chinese persons, 1.5% of Japanese persons, 1 to 12% of Indians, and 2 to 4% of Southeast Asians but is largely absent in Europeans and Africans."

Treatment of choice

Use for

Leprosy, PJP.

Don't use for

Class

Sulphone. Can you hear me?