Infectious Disease Compendium

Dalbavancin

Dosing

(PubMed)

CrCl Formula

CrCl > 30: 1 gram load then 500 mg every week. Yes, week. It has a very long half life.

CrCl < 30: 750 mg followed one week later by 375 mg.

Hemodialysis:

Peritoneal dialysis:

Important side effects

None to date.

Red man syndrome

Important drug interactions

Rants and Screeds

Dalbavancin 2 dose administration (1000 mg, followed by 500 mg in 7 days): $2,835.48 + $1,417.74 = $4,253.22. Are you kidding me? This decade has seen a resurgance in price gouging for antibiotics.

Pearls

Treatment of choice

Use for

Approved for soft tissue infections.

All gram postive including VRE (not great) and MRSA. Same spectrum as vancomycin, but much better MIC's. Only approved for cellulitis, for which it is no worse than vancomycin (PubMed); the definition of damning with faint praise I suppose.

Don't use for

Class

Lipoglycopeptide.