Infectious Disease Compendium

Cycloserine (Seromycin®)

Dosing

CrCl Formula

CrCl > 80: 250 - 500 mg po bid, usually the lower dose.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Mostly neurologic including absence seizures, catatonia, coma, confusion, dysarthria, headache, hyperreflexia, irritability, nervousness, paranoia, paresis, psychosis, somnolence, tonic-clonic seizures, tremor, twitching, vertigo, visual disturbances.

Important drug interactions

Concomitant use of cycloserine and ethionamide or cycloserine and isoniazid can increase CNS toxicity.

Rants and Screeds

Pearls

Treatment of choice

Second line for tuberculosis.

And consider cyloserine for resistant E. coli UTI's. Yes, it's a TB drug, but it is effective against gram negative rods (PubMed).

Use for

Don't use for

Class