Infectious Disease Compendium

Cloxacillin

Dosing

CrCl Formula

CrCl > 80: 500 - 1000 mg q 6 h po.

CrCl 80-50: 500 - 1000 mg q 6 h po.

CrCl 50-10: 500 - 1000 mg q 6 h po.

CrCl < 10: 500 - 1000 mg q 6 h po.

Hemodialysis: 500 - 1000 mg q 6 h po.

Peritoneal dialysis: 500 - 1000 mg q 6 h po.

Important side effects

High dose iv may be associated with AKI in the elderly. (PubMed)

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Staphylococcus and streptococcus.

Use for

Don't use for

Class

Penicillin.