Infectious Disease Compendium

Clofazimine (Lamprene®)

Dosing

CrCl Formula

CrCl > 80: 50 mg q d.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

in eye: dryness, burning, itching, irritation and conjunctival and corneal pigmentation and skin pigmentation.

Important drug interactions

Antacids (decreases clofazimine), fosphenytoin and phenytoin (decreases fosphenytoin and phenytoin)

Rants and Screeds

Pearls

Treatment of choice

Used in multidrug rx of leprosy.

Use for

M. chelonae, M. abscessus, and M. avium-intracellulare.

Don't use for

Class