Infectious Disease Compendium

Clindamycin (Cleocin®)

Dosing

CrCl Formula

CrCl > 80: 150 mg - 900 mg q 6 -8 iv or po.

CrCl 80-50: no change.

CrCl 50-10: no change.

CrCl < 10: no change.

Hemodialysis: no change.

Peritoneal dialysis: no change.

Obesity dosing

Important side effects

#1 cause of C. difficile colitis. May be. Quinolones are driving C. difficile of late.

Important drug interactions

Atracurium, cisatracurium, cyclosporine, doxacurium, erythromycin, erythromycin/sulfisoxazole, gallamine, kaolin, metocurine, mivacurium, pancuronium, pipecuronium, rocuronium, tubocurarine, vecuronium.

Rants and Screeds

Pearls

30% of bacteroides and oral streptococci are now resistant.

Treatment of choice

Use to decrease toxin production in all forms of Toxic Shock Syndrome.

Use for

Acne, Anaerobes, Anthrax, Babesia microti, bacterial Endocarditis prophylaxis, Bacterial vaginosis, bacteroides infections, Diverticulosis/itis, Endometritis, Intra abdominal infections, intraocular infections, Microsporidia, PID, peridonitis, Pneumocystis prophylaxis, and treatment, Staphylococcus aureus, Staphylococcus, coag negative, Streptococci, surgery prophylaxis, Toxoplasma.

Don't use for

Class

Lincosamide.