Infectious Disease Compendium

Chloroquine (Aralen®)

Dosing

CrCl Formula

CrCl > 80: 600 mg base (1000 mg chloroquine phosphate) PO, then 300 mg base (500 mg salt) 6 hr later, and again on days 2 and 3.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

EKG changes,, decrease in hearing, long term can lead to retinal degeneration and blindness as well as many other side effects.

Important drug interactions

WITH THE EXCEPTION OF antacids and kaolin, which decrease absorption, ALL OF THE FOLLOWING WILL INCREASE THE QT and could lead to cardiac death: antipsychotics, arsenic trioxide, astemizole, aurothioglucose, bepridil, chloral hydrate, chloroguanide, cimetidine, cisapride, clarithromycin, class i antiarrhythmic agents, class ia antiarrhythmic agents, class iii antiarrhythmic agents, cotrimoxazole, cyclosporine, dolasetron, droperidol, enflurane, erythromycin, erythromycin/sulfisoxazole, fluconazole, fluoxetine, foscarnet, gemifloxacin, halofantrine, halothane, isoflurane, isradipine, kaolin, levomethadyl, levothyroxine, lidoflazine, mefloquin, mesoridazine, octreotide, pentamadine, phenothiazines, pimozide, praziquantel, probucol, spiramycin, sulfamethoxazole, telithromycin, terfenadine, thioridazine, tricyclic antidepressants, trimethoprim, vasopressin, venlafaxine, ziprasidone, zolmitriptan.

Rants and Screeds

Pearls

Treatment of choice

Malaria.

Use for

Don't use for

Class

4-aminoquinoline derivative.