Infectious Disease Compendium

Cephalothin (Keflin®)

Dosing

CrCl Formula

CrCl > 80: 500 mg - 2 g q 4 - 6 h iv.

CrCl 80-50: 500 mg - 2 g q 4 - 6 h iv.

CrCl 50-10: 1-1.5 g q 6 h iv.

CrCl < 10: 500 mg q 8 h iv.

Hemodialysis: 500 mg - 2 g after dialysis.

Peritoneal dialysis: na.

Important side effects

Important drug interactions

Rants and Screeds

Pearls

Treatment of choice

Use for

Streptococci of all types and methicillin susceptible S. aureus. Arthritis, Cellulitis, Pneumonia, Osteomyelitis, surgical prophylaxis, UTI.

Don't use for

Class

First generation cephalosporin.