Infectious Disease Compendium

Cefuroxime (Zinacef®)


CrCl Formula

CrCl > 80: 750 mg - 1.5 g q 12 h iv.

CrCl 80-50: .750 - 1.5 g q 12 h iv.

CrCl 50-10: .750 - 1.5 g q 12 h iv.

CrCl < 10: 250 mg iv q 24 h iv.

Hemodialysis: 750 mg after dialysis.

Peritoneal dialysis:

Important side effects

Important drug interactions

Rants and Screeds


Treatment of choice

Use for

Arthritis, Bronchitis, Cellulitis, Gonorrhea, Haemophilus influenzae infections, Lyme Disease, maxillofacial infections, Meningitis (but don't use it for meningitis), Moraxella catarrhalis infections, Osteomyelitis, Otitis media, PID, Pharyngitis/tonsillitis, Pneumonia, Sinusitis, surgical prophylaxis, UTI.

Don't use for


Second generation cephalosporin.