CrCl > 80: 1.5 g (1 g/0.5 g) every 8 hours
CrCl < 10:
Important side effects
Important drug interactions
Rants and Screeds
$2,490/day. Really. I know it costs real money to bring a drug to market and all but WTF?!?
Treatment of choice
Enhanced activity against Pseudomonas aeruginosa and activity against ESBL organisms.
Ceftolozane/tazobactam is more potent against P. aeruginosa compared to ceftazidime, cefepime, meropenem, pipercillin/tazobactam, aztreonem, levofloxacin, gentamicin and colistin. Second to colistin, had best activity against 310 multidrug resistant strains of P. aeruginosa. Similarly 175 extensively drug resistant strains showed susceptibility, while they were resistant to most other agents. Ceftolozane/tazobactam has activity against Bacteroides fragilis but not the remainder of Bacteroides spp.
Don't use for