Infectious Disease Compendium

Ceftolozane/tazobactam (Zerbaxa®)

Dosing

CrCl Formula

CrCl > 80: 1.5 g (1 g/0.5 g) every 8 hours

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Rants and Screeds

$2,490/day. Really. I know it costs real money to bring a drug to market and all but WTF?!?

Pearls

Treatment of choice

Use for

Enhanced activity against Pseudomonas aeruginosa and activity against ESBL organisms.

Ceftolozane/tazobactam is more potent against P. aeruginosa compared to ceftazidime, cefepime, meropenem, pipercillin/tazobactam, aztreonem, levofloxacin, gentamicin and colistin. Second to colistin, had best activity against 310 multidrug resistant strains of P. aeruginosa. Similarly 175 extensively drug resistant strains showed susceptibility, while they were resistant to most other agents. Ceftolozane/tazobactam has activity against Bacteroides fragilis but not the remainder of Bacteroides spp.

Don't use for

Class