Infectious Disease Compendium

Ceftazidime/avibactam (Avycaz®)(Pubmed)

Dosing

CrCl Formula

CrCl > 80: 2.5 g every 8 hours

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Rants and Screeds

$332 a dose as of 10/1/16. Ouch.

Pearls

Treatment of choice

Use for

Adding avibactam to ceftazidime increases activity against carbapenem-resistant pathogens with OXA-48, KPC, AmpC (including derepressed hyperproducing Enterobacter17), and andhas similar spectrum/coverage against ESBLs as carbapenems.

 

Don't use for

Metallo-beta-lactamases are not inhibited by avibactam.

Treating carbapenam resistant E. coli and K. pneumoniae has a high failure rate (PubMed)

Class