Infectious Disease Compendium

Cefotaxime (Claforan®)

Dosing

CrCl Formula

CrCl > 80: 500 mg - 2 gm iv q 8 - 12 h.

CrCl 80-50: 500 mg - 2 gm iv q 8 - 12 h.

CrCl 50-10: 500 mg - 2 gm iv q 12 -24 h.

CrCl < 10: 500 mg - 2 gm iv q 24 h.

Hemodialysis: 500 mg - 2 gm after dialysis.

Peritoneal dialysis:

Important side effects

Important drug interactions

Rants and Screeds

Pearls

Although considered equal to ceftriaxone, resistance may be worse for this antibiotic (PubMed).

Treatment of choice

Use for

Anything you would use a third-generation cephalosporin for. Most streptococci and the Enterobacteriaceae.

Abdominal hysterectomy, Arthritis, Brain abscess, Cellulitis, Endocarditis, Endometritis, Flavobacterium infections, Gonorrhea, Intraabdominal infections, Lyme Disease, Meningitis, Osteomyelitis, PID, Peritonitis, Pneumonia, Salmonella infections, Sepsis, surgical prophylaxis, UTI, ventriculitis.

Don't use for

Pseudomonas and its ilk. S. aureus. Enterococcus.

Class

Third-generation cephalosporin.

Last Update: 08/05/19.