Infectious Disease Compendium

Cefoperazone (Cefobid®)

Dosing

CrCl Formula

CrCl > 80: 1 - 2 g iv q 6 - 12 h.

CrCl 80-50: 1 - 2 g iv q 6 - 12 h.

CrCl 50-10: 1 - 2 g iv q 6 - 12 h.

CrCl < 10: 1 - 2 g iv q 6 - 12 h.

Hemodialysis: dose after dialysis

Peritoneal dialysis:

Important side effects

Hypoprothrombinemia with increase in protime.

Important drug interactions

Heparin, warfarin due to hypoprothrombinemia with increase in protime.

Rants and Screeds

Pearls

Treatment of choice

Use for

Any thing you would use a third generation cephalosporin for. Cellulitis, Cholangitis, Cholecystitis, Gonorrhea, Intra abdominal infections, PID, Peritonitis, Pneumonia, Meningitis, ocular infections, Osteomyelitis, Otitis media, peritoneal dialysis, Peritonitis, proteus mirabilis infections, Pneumonia, Sepsis, UTI.

Don't use for

Class

Third generation cephalosporin.