Infectious Disease Compendium

Cefamandol (Mandol®)

Dosing

CrCl Formula

CrCl > 80: 500 mg - 2 g q 4 - 8 h iv.

CrCl 80-50: 500 mg - 2 g q 6 h iv.

CrCl 50-10: 500 mg - 2 g q 8 h iv.

CrCl < 10: 500 mg - 1 g q 12 h iv.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Heparin coagulation abnormalities due to a direct effect on prothrombin time or vitamin K production. Warfarin hypoprothrombinemia and/or prolonged bleeding time.

Rants and Screeds

Pearls

Treatment of choice

Use for

Arthritis, Osteomyelitis, Peritonitis, Pneumonia, surgical prophylaxis.

Don't use for

Class

Second generation cephalosporin.