Infectious Disease Compendium

Capreomycin (Capastat®)

Dosing

CrCl Formula

CrCl > 80: 1 gm IM or IV q 24 h.

CrCl 80-50: 1 gm IM or IV q 24 h.

CrCl 50-10: 7.5 mg/kg q 24 - 48 h IM or IV.

CrCl < 10: 7.5 mg/kg IM or IV 2x / wk.

Hemodialysis:

Peritoneal dialysis:

Important side effects

Abnormal LFT's, eosinophilia, hypokalemia, injection site pain, nephrotoxicity, ototoxicity, urticaria, maculopapular rash.

Important drug interactions

Increased ototoxic or nephrotoxic potential with other drugs with this effect.

Rants and Screeds

Pearls

Treatment of choice

Use for

Mycobacterium tuberculosis (second line drug).

Don't use for

Class