Infectious Disease Compendium

Aztreonam (Azactam)

Dosing

CrCl Formula

CrCl > 80: 1-2 gm q 6 h.

CrCl 80-50: q 8-12 h.

CrCl 50-10: q 12 - 18 h.

CrCl < 10: q 24 h.

Hemodialysis 1/8 initial dose.

Peritoneal dialysis:

Obesity dosing

Important side effects

No unusual.

Important drug interactions

No unusual.

Rants and Screeds

Pearls

Safe with anaphylactic reactions to other beta lactams.

Treatment of choice

Use for

Gram negative aerobic organisms like E. coli and Pseudomonas.

Don't use for

All gram positives. And for ESBL, which hydrolizes aztreonam.

Class

Monobactam