Infectious Disease Compendium

Atovaquone (Mepron®)

Dosing

CrCl Formula

CrCl > 80: 750 mg po bid of the suspension (5 ml). Only use the suspension with a high fat meal. Better absorption.

CrCl 80-50:

CrCl 50-10:

CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Important drug interactions

Combination of atovaquone with metoclopramide may result in decreased bioavailability of atovaquone; Combination of rifabutin and atovaquone may result in reduced serum concentrations of atovaquone by 34% ; Combination of rifampin reduces atovaquone levels by approximately 50%; Combination of ritonavir and atovaquone may result in decreased serum concentrations of atovaquone; Combination of tetracycline and atovaquone is associated with a reduced serum concentrations of atovaquone by 40%.

Rants and Screeds

Pearls

Treatment of choice

Use for

PJP, Malaria, Toxoplasmosis, Babesia.

Don't use for

Class

Antiprotozoal.