Infectious Disease Compendium

Amprenavir (Agenerase®)

Dosing

No longer in the US, use fosamprenavir.

CrCl Formula

For up-to-date information, go tohttp://hivinsite.ucsf.edu/tables.

CrCl > 80: 1200 mg po bid. When combined with ritonavir 200 mg once daily, amprenavir 1200 mg po once daily.

CrCl 80-50: contraindicated in renal and hepatic insufficiency.

CrCl 50-10: CrCl < 10:

Hemodialysis:

Peritoneal dialysis:

Important side effects

Rash. If a rash occurs on therapy the drug is to be stopped and never restarted as it will go on to Stevens Johnson and kill the patient; diabetes, body fat redistribution, lipid abnormalities.

Important drug interactions

Concomitant use of rifampin, St. John's wort, lovastatin, simvastatin, or delavirdine is NOT recommended; Drugs that interact adversely include alprazolam, amiodarone, amlodipine, antacids, astemizole, atorvastatin, bepridil, cannabis, carbamazepine, cerivastatin, cisapride, clorazepate, cyclosporine, dapsone, delavirdine, dexamethasone, diazepam, didanosine, dihydroergotamine, diltiazem, disulfiram, efavirenz, eletriptan, ergonovine, ergotamine, ethinyl estradiol, felodipine, fentanyl, flurazepam, fosphenytoin, garlic, indinavir, isradipine, itraconazole, ketoconazole, levonorgestrel, lidocaine, lovastatin, mestranol, methadone, methylergonovine, metronidazole, midazolam, nelfinavir, nevirapine, nicardipine, nifedipine, nimodipine, nisoldipine, norelgestromin, norethindrone, norgestrel, phenobarbital, phenytoin, pimozide, pravastatin, quinidine, rifabutin, rifampin, rifapentine, ritonavir, saquinavir, sildenafil, simvastatin, sirolimus, st john's wort, tacrolimus, tadalafil, terfenadine, triazolam, tricyclic antidepressants, vardenafil, verapamil, voriconazole, warfarin. Look them up.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV

Don't use for

Class

Protease inhibitor.