Infectious Disease Compendium

Ampicillin/Sulbactam (Unasyn®)


CrCl Formula

CrCl > 80: 1.5 - 3.0 g q 6-8 h.

CrCl 80-50: 1.5 - 3.0 g q 6-8.

CrCl 50-10: 1.5 - 3.0 g q 8-12 h.

CrCl < 10: 1.5 - 3.0 g q 24 h.


Peritoneal dialysis:

Obesity dosing

Important side effects

Important drug interactions

Rants and Screeds

What is really moronic is how often people give this for streptococcal infections. Strep don't make a beta lactamase, so all you add is cost without benefit. Where I practice, 30% of E. coli are resistant, so I do not suggest it for intra abdominal infections. Not bad for anaerobes.


Treatment of choice

Use for

I have never found a use for this drug. I suppose one exists, e-mail me if you find one. For Dr. Gicking, as I forgot to put this in the first several drafts: I spell it Uni Sin.

Some use it for: Animal bites, Carbuncles, Cellulitis, Chancroid, Diverticulosis/itis, Gonorrhea, lymphadenitis, Mastitis, mycetoma, Nocardia, Otitis media, periodontitis, Pharyngitis, Pneumonia, tonsillitis, UTI.

Don't use for


Penicillin/beta lactamase inhibitor combination.