Infectious Disease Compendium

Amoxicillin/Clavulanate (Augmentin®)

Dosing

CrCl Formula

CrCl > 80: 250-500 mg q 8 h or 875 mg po q 12 h.

CrCl 80-50: 250-500 mg q 8 h. CrCl 50-10: q 12 h.

CrCl < 10: q 12-24 h.

Hemodialysis: 250 mg after dialysis.

Peritoneal dialysis:

Important side effects

Diarrhea.

Important drug interactions

Rants and Screeds

No streptococcus makes a beta lactamase, so it is way moronic to give this agent when you are worried about a streptococcus.

Pearls

Treatment of choice

In my opinion, nothing. A drug without a use.

Use for

Animal bite prophylaxis. The only use for this drug in my never humble opinion. Unless, of course, you like to give your patients diarrhea.

Don't use for

Anything else. Ever. Wouldn't be prudent. Others use it for Animal bites, Carbuncles, Cellulitis, Chancroid, Diverticulosis/itis, Gonorrhea, lymphadenitis, Mastitis, mycetoma, Nocardia, Otitis media, periodontitis, Pharyngitis, Pneumonia, tonsillitis, UTI.

Class

Penicillin.