Infectious Disease Compendium

Albendazole (Eskazole®, Zentel®)

Dosing

CrCl Formula

CrCl > 80: dose varies depending on the parasite you are treating.

Ancylostoma caninum: 400mg po as a single dose.

A. lumbricoides: 400mg po as a single dose.

Clonorchis sinensis: 10mg/kg po daily for 7 days.

Cutaneous larva migrans (dog, cat hookworm): 400mg po daily for 3 days.

E. vermicularis: 400mg po as a single dose; repeat in 2 weeks.

Filariasis (mansonella perstans): 400mg po twice daily for 10 days.

Gnathostoma spinigerum: 400mg po twice daily for 21 days.

Hookworm (A. duodenale, N. americanus): 400mg po as a single dose.

Echinococcus: 60kg or greater, 400mg po twice daily for three 28-day cycles.
Hydatid Disease: less than 60kg, 15mg/kg/day po in two divided doses for three 28-day cycles, maximum dose 800mg/day.

Microsporidia: (ocular) 400mg po twice daily; (intestinal due to E intestinalis) 400mg po twice daily for 21 days; (disseminated) 400mg po twice daily.

Neurocysticercosis: 60kg or greater, 400mg po twice daily for 8-30 days.

Neurocysticercosis: less than 60kg, 15mg/kg/day po in two divided doses for 8-30 days, maximum dose 800mg/day.

Visceral larva migrans (toxocariasis): 400mg po twice daily for 5 days.

CrCl 80-50: do not need to alter dose for renal dysfunction.

CrCl 50-10: do not need to alter dose for renal dysfunction.

CrCl < 10: do not need to alter dose for renal dysfunction.

Hemodialysis: do not need to alter dose for renal dysfunction.

Peritoneal dialysis:

Important side effects

Hair loss, increased LFT's, rarely leukopenia.

Important drug interactions

Dexamethasone and prazequantil both increase drug levels; grapefruit juice increases gi uptake.

Rants and Screeds

Pearls

Treatment of choice

Use for

A. lumbricoides, A. duodenale, Clonorchis sinensis, E. vermicularis, Cutaneous larva migrans, C. philippinensi, Filariasis, Echinococcus, Gnathostoma spinigerum, N. americanus, Neurocysticercosis, Trichostrongylus spp. T. trichiura, Visceral larva migrans.

Don't use for

Class

Benzimidazole carbamate antihelmintic.