CrCl > 80:
HIV: 125 mg po qd.
CrCl 50 or greater: 10 mg every 24 hours.
CrCl 20 to 49: 10 mg every 48 hours.
CrCl 10 to 19: 10 mg every 72 hours.
CrCl less than 10: no dosing recommendation.
CrCl hemodialysis: 10 mg every 7 days following dialysis.
Important side effects
nephrotoxicity, decreases in phosphorus, hepatitis.
Important drug interactions
Rants and Screeds
Treatment of choice
HIV; Hepatitis B.At least that is what they are tested for. I suggest not using it for either disease, for HIV use tenofivir (Thanks Sally). Use after a failure of lamivudine in e antigen positive patients.
Don't use for
acyclic nucleotide analogue.