Infectious Disease Compendium

Abacavir (Ziagen®)

Other formulations

trizavir ® is abacavir + zidovudine + lamivudine is dosed 1 po bid.

Dosing

CrCl Formula

For up-to-date information, go to http://hivinsite.ucsf.edu/.

CrCl > 80: 300 bid oor 600 qd.

CrCl 80-50: unknown

CrCl 50-10: unknown

CrCl < 10: unknown

Hemodialysis: unknown

Peritoneal dialysis: unknown

Important side effects

3% get a hypersensitivity reaction (esp white males with HLA B5701: 50-70%. Also, if genotyping of the HIV shows a mutation at codon 245 have a very high chance of being HLA B5701 (PubMed, PubMed).Testing for HLA (and it is becoming standard of care) can prevent the reaction (PubMed)): rash, increased LFT's cytopenia's, nausea. Rechallange can KILL, as can continuing the drug. Lactic acidosis and hepatomegaly with steatosis.

Important drug interactions

Increases amprenavir effect and toxicity; with ribavirin increases risk of lactic acidosis; decreases methadone effect.

Rants and Screeds

Pearls

Treatment of choice

Use for

HIV.

Don't use for

Class

Nucleoside reverse transcriptase inhibitor.