Pain and burning with urination.
Per CDC: Mucopurulent or purulent discharge. Gram stain of urethral secretions demonstrating >5 WBCs per oil immersion field. Gonococcal infection is established by documenting the presence of WBC's containing intracellular Gram-negative diplococci. Positive leukocyte esterase test on first-void urine or microscopic examination of first-void urine demonstrating >10 WBC's per high power field.
Often a sexually transmitted disease.
In one study C. trachomatis, M. genitalium, M. hominis, U. parvum biovar 1, and U. urealytiucm biovar 2 were detected in 21.8%, 4.1%, 2.1%, and 8.5%, respectively.
In patients with chlamydia-negative GU, coinfection with M. genitalium was associated with a 14.54-fold greater risk of PGU and coinfection with U. urealyticum biovar 2 was associated with a 3.64-fold greater risk of PGU (PubMed).
per the CDC.
Alternative Regimens erythromycin base 500 mg orally four times a day for 7 days OR erythromycin ethylsuccinate 800 mg orally four times a day for 7 days OR levofloxacin 500 mg orally once daily for 7 days OR ofloxacin 300 mg orally twice a day for 7 days.
Recommended Treatment for Recurrent / Persistent Urethritis
Persistence after therapy for NGU depends on what you used for treatment (PubMed):
"...persistent Chlamydia in 12% and MG in 44% of participants at 4 weeks after therapy, which was associated with signs and symptoms of NGU. Persistent Chlamydia was detected in 23% of participants after azithromycin treatment vs 5% after doxycycline treatment (P = .011); persistent Mycoplasm was detected in 68% of participants after doxycycline vs 33% after azithromycin (P = .001). All but 1 Trichomonas infection cleared after tinidazole."
Expect a 25% failure rate no matter what you give (PubMed).
Last Update: 04/02/19.