Infectious Disease Compendium

Immunodeficiency Common Variable Immunodeficiency

Diagnosis

(PubMed)

An immunoglobulin deficiency.

Syndromes

Bronchitis, Sinusitis, Pneumonia, Bronchiectasis, Sepsis, Endocarditis, Meningitis, Chronic diarrhea, Splenomegaly, Autoimmune cytopenia, Liver disease.

Microbiology

(In rough order of desending incidence) Streptococcus pneumoniae, Haemophilus influenzae, Giardia intestinalis, Salmonella species, Campylobacter species, Clostridium difficile, Yersinia enterolitica, Chronic Hepatitis C, Neisseria meningitidis, Staphylococcus aureus skin abscess, recurrent Varicella Zoster, invasive HPV infection or profuse warts, severe Varicella Zoster, oral Candida, severe infectious mononucleosis (Epstein Barr virus), Ocular Toxoplasma, visceral mycosis, visceral Cytomegalovirus infection, Pneumocystis pneumonia, Cryptosporidium diarrhea, cerebral Toxoplasma, systemic adenovirus infection, Kaposi sarcoma.

Treatment

Monthly immunoglobulin infusions; is only moderately effective in decreasing infections.