Infectious Disease Compendium



Endemic non venereal syphilis.

It is a chronic skin starting as painless mucous membrane ulcers then periostitis of the leg bones and gummas of the nose and soft palate.

Epidemiologic Risks

Person to person, especially among the poor by mouth-to-mouth contact or sharing of utensils. Mostly found eastern Mediterranean and West Africa .


T. pallidum subsp. endemicum.

Empiric Therapy

1.2 IM benzathine penicillin one time.

Last Update: 05/10/18.