Infectious Disease Compendium



Epidemiologic Risks


Acute mycoplasma can cause a severe hemolytic anemia, I have seen a Hgb of 2 as can a new Mycoplasma (Hemoplasma) (PubMed).

Parvovirus B19, which kills stem cells. If the patient relies of increased output to maintain their HCT (ex: sickle cell) they can become acutely anemic. Treatment is supportive. AIDS patients can get severe refractory anemia with a parvovirus infection as they do not make antibody against the virus. AIDS patients are seronegative and the diagnosis is made by bone marrow biopsy that shows giant pronormoblasts or blood for PCR for parvovirus. The treatment for AIDS is monthly IVIG.

Occasionally anemia can be due to Malaria or Babesia.

Acute Clostridia infections can cause a severe hemolytic anemia, by the time you make the diagnosis the patient is dead.

Empiric Therapy

Besides transfusion (duh), depends in the cause.