Infectious Disease Compendium

Sporothrix

Microbiology

A fungus. Sporothrix schenckii (PubMed). In Asia it is Sporothrix globosa. Also Sporothrix brasiliensis and S. mexicana and others (PubMed).

Epidemiologic Risks

Found in rotting organic material, it is most often due to percutaneous injury. Cats can be a vector and can get the disease (PubMed) as can the scratches or biteof mice, armadillos, squirrels and dogs.

Worldwide, especially in tropical and subtropical parts of the world.

A problem in armadillo hunters in Uruguay.

Syndromes

Ascending nodular lymphangitis (it forms bumps in the lymphatics where the nodes are not), occasionally infected joints and pneumonia (primarily in poor hosts).

AIDS patients can get a disseminated disease (PubMed).

Sporothrix globosa causes sapronose: "human diseases transmissible from abiotic environment (soil, water, decaying plants, or animal corpses, excreta, and other substrata)(PubMed)."

Sporothrix brasiliensis: chronic meningitis with hydrocephalus often in poor hosts (PubMed).

Treatment

A saturated solution of potassium iodide (SSKI) begin with 5 to 10 drops po tid and increase to 40 to 50 drops tid is the traditional treatment.

Cutaneous disease can be treated with itraconazole at 100 mg/d (duration is until all gone) (PubMed) and widespread disease usually treated with amphotericin B.

Terbinafine and posaconazole look good in vitro.

Susceptibility is strain dependent (PubMed), so as always get sensitivities if you can.

Notes

Forget about the rose thorn as the specific risk, it is a nice source of a puncture wound, but any puncture covered with organic material can cause disease. Sphagnum moss and hay are good sources as well.

Last Update: 06/02/18.