Infectious Disease Compendium

Scedosporium (aka Pseudallescheria)


A fungus, includes S. apiospermum, S. prolificans (inflatum).

Epidemiologic Risks


The occasional pneumonia and disseminated disease in the immunoincompetent, skin and joint infections in normal hosts. Can also cause eye infection after penetrating injury.


Possibly, maybe, perhaps voriconazole, posaconazole and ravuconazole based on in vitro reports and a smattering of case reports. Usually resistant to amphotericin B, fluconazole, intermediate to caspofungin. In one series, if susceptible, about 60% of patients responded to long term voriconazole (PubMed), esp if they were infected with Scedosporium prolificans.