Infectious Disease Compendium

Cutibacterium (formally known as Propionibacterium)


Anaerobic gram positive rod, P. acnes. As of 2018 the Propionibacterium (PubMed),  P. humerusii, P. namnetense, P. acnes , P. avidum, P. granulosum are all now Cutibacterium. For now (1/1/18) I am not going to change the text in the Compendium until the name change is more established.

Epidemiologic Risks

Lives in hair follicles and is protected from both topical and systemic antibiotics (PubMed).


Often a contaminant in the LP that grows on day 5 in the thio only. If cultured anaerobically, Propionibacterium acnes may account for 15% of catheter infections (PubMed).

Post op wound infections where there is hair, often associated with devitalized tissue or prosthetic material. There can be months between the surgery and the clinical manifestation of the disease. Given its association with hair, it is found as a problem with neurosurgical operations: VP shunts, laminectomy infections, craniotomy infections, discitis is a commoner manifestation.

Propionibacterium acnes may be a cause of prosthetic joint infections, especially after shoulder surgery (PubMed). My son, at this writing six years old, uses the word worser; I have taken the liberty of extending the neologism.  Perhaps because it is normal flora, the ususal inflammatory markers may be normal.

P. avidum associated with prosthetic joints (PubMed).

In a series of 522 patients with P. acnes bacteremia, 3.5% of isolates turned out to be significant (PubMed). I do not think I have seen one, much less 522. Makes one wonder about their blood culture technique, or perhaps it was an adolescent hospital.

It may cause/be associated with the SAPHO syndrome (seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis with and without sterile multifocal osteomyelitis. Sounds unpleasant). and treatment decreases symptoms (Online ref).


Penicillin OR clindamycin. In the test tube the best killing occurs with a combination of vancomycin PLUS ceftriaxone.


Although I often say the three most dangerous words in medicine are "In my experience", in my experience clindamycin works better. So there. BTW. It is usually resistant to metronidazole.