Virus. NEJM Review.
Fecal oral, there is evidence of human to human spread. Mostly its eating pig meat, innards, home-prepared pork products, or tasting raw pigmeat. One guy got it from his pet pig. Really. In Denmark ( PubMed) and Germany ( PubMed) it is mostly an asymptomatic zoonoses from eating swine and wild boars. Espcially common after flooding.
About 21% of Americans are seropositive ( PubMed) although studies have put it at 6% ( PubMed); pets and eating liver are the risks; I assume these risks are rarely combined. I bet Hannibal Lecter is seropositive.
It is in the Red Deer in Spain ( PubMed). I thought Franco got rid of all the Reds. In Rabbits in West Virginia and France. And rats in LA ( PubMed). And ferrets. And eating camel meat and mild ( PubMed). There goes my diet.
It has been passed on by transfusions.
Can be chronic in them what have bad immune systems ( PubMed). In HIV patients with unexplained increased ALT, chronic hepatitis E was found in 2.6%, so it wasn't so unexplained, was it?
Pregnant women in Asia die and use of acetaminophen is a risk for death ( PubMed).
There are a smattering of cases of encephalitis.
Supportive. Highly effective (95%) vaccine is in the works ( PubMed).