Infectious Disease Compendium

Human Papilloma Virus

Microbiology

A papilloma virus, hence the name.

Epidemiologic Risks

Sex.

"any genital HPV prevalence among adults aged 18–59, was 42.5% in the total population, 45.2% among men and 39.9% among women; high-risk genital HPV prevalence was 22.7% in the total population, 25.1% among men and 20.4% among women. (PubMed). Frank Drebin had it right.

In heterosexual men, the prevalence of HPV was 18.7% at the penis, 13.1% at the scrotum, 7.9% at the perineal/perianal region, and 21.0% at any site (PubMed). In homosexual men it was 18.5% at the penis, 17.1% at the scrotum, 33.0% at the perineal/ perianal region, 42.4% in the anal canal, and 48.0% at any site (PubMed).

Risk of spread in discordant couples is 3.5/100 person months or a per-partnership transmission probability of 0.20 which is a number not even statisticians understand (PubMed). You want to know risk per episode of sex.

Syndromes

Veneral warts, cancer of the cervix, rectum, and oral pharyngeal cancer (I wonder how it gets to the throat?) (PubMed).

Treatment

There is a vaccine. It prevents cancer. That should be considered a good thing.

Besides females, "Advisory Committee on Immunization Practices (ACIP) recommended routine use of quadrivalent human papillomavirus (HPV) vaccine in males aged 11 or 12 years. ACIP also recommended vaccination with HPV4 for males aged 13 through 21 years who have not been vaccinated previously or who have not completed the 3-dose series; males aged 22 through 26 years may be vaccinated. (MMWR)"

Notes

Herd immunity works. Vaccination of females leads to decreased disease in unvaccinated females and in males, the vector.