Infectious Disease Compendium

Granulibacter

Microbiology

Granulibacter bethesdensis. Gram-negative bacterium in the family Acetobacteraceae

Epidemiologic Risks

Syndromes

Prolonged fever and necrotizing lymphadenitis in patients with Chronic Granulomatous disease.

Half of CGD patients are seropositive; 25% of normal react as well, so exposure is common, but disease (PubMed)?

Treatment

"This organism shows extensive resistance to most cephalosporins, penicillins (including carbapenems), and quinolones. However, ceftriaxone (MIC 8 ?g/mL), aminoglycosides (e.g., gentamicin, MIC 8 ?g/mL), doxycycline, and trimethoprim/sulfamethoxazole show activity in vitro. Our patients were treated with various combinations of these drugs; all showed initial resolution of disease. Ceftriaxone is currenty our preferred treatment (PubMed)".

Relapse is the norm in CGD.

Notes

ICD9 Codes (Soon to be supplanted by ICD10)