Granulibacter bethesdensis. Gram-negative bacterium in the family Acetobacteraceae.
Ubiquitous environmental organism in soil and on plants.
Half of CGD patients are seropositive; 25% of normal react as well, so exposure is common, but disease (PubMed)?
"This organism shows extensive resistance to most cephalosporins, penicillins (including carbapenems), and quinolones. However, ceftriaxone (MIC 8 ug/mL), aminoglycosides (e.g., gentamicin, MIC 8 ug/mL), doxycycline, and trimethoprim/sulfamethoxazole show activity in vitro. Our patients were treated with various combinations of these drugs; all showed initial resolution of disease. Ceftriaxone is currenty our preferred treatment (PubMed)".
Relapse is the norm in CGD.
Last update: 05/05/18