Infectious Disease Compendium

Granulibacter

Microbiology

Granulibacter bethesdensis. Gram-negative bacterium in the family Acetobacteraceae.

Epidemiologic Risk

Ubiquitous environmental organism in soil and on plants.

Syndromes

Prolonged fever and necrotizing lymphadenitis in patients with chronic granulomatous disease (PubMed)(PubMed).

Half of CGD patients are seropositive; 25% of normal react as well, so exposure is common, but disease (PubMed)?

Treatment

"This organism shows extensive resistance to most cephalosporins, penicillins (including carbapenems), and quinolones. However, ceftriaxone (MIC 8 ug/mL), aminoglycosides (e.g., gentamicin, MIC 8 ug/mL), doxycycline, and trimethoprim/sulfamethoxazole show activity in vitro. Our patients were treated with various combinations of these drugs; all showed initial resolution of disease. Ceftriaxone is currenty our preferred treatment (PubMed)".

Relapse is the norm in CGD.

Notes

Last update: 05/05/18