Infectious Disease Compendium

Fusarium

Microbiology

A mold (or mould) Fusarium solani (Review) is the most common human pathogen and a huge bunch of others.

Epidemiologic Risks

Found in decaying soils. Many are plant pathogens.

Syndromes

Local and, more commonly, disseminated disease in neutropenic patients. Worry it is the cause of any red/necrotic bump (it gets there hematogenously) in prolonged neutropenic fever with myalgias. Occasionally will involve severe burns.

In Brazil it is a cutaneous disease (PubMed). Someone want to send me during Carnival to check it out?

Treatment

Maybe posaconazole at maximum doses or voriconazole (MIC 8) are maybe as good as amphotericin B (PubMed, PubMed); it can be resistant to amphotericin B (MIC >16).

And if you can remove any of the infection surgically, do it. Debridement always the best therapy.

Notes

"Fusarium venenatum is produced industrially for use as a human food by Marlow Foods, Ltd. (mmmmm) and
Mass casualties occurred in the Soviet Union in the 1930s and 1940s when Fusarium-contaminated wheat flour was baked into bread, causing alimentary toxic aleukia with a 60% mortality rate (PubMed) ."

Last update: 05/05/18