Infectious Disease Compendium

Emmonsia

Microbiology

A dimorphic mold (or mould) Emmonsia crescens, Emmonsia parva, Emmonsia pasteuriana.

Epidemiologic Risks

Most cases are in South Africa.  The fungus is worldwide, a rat (and other mammals) pathogen, that causes Adiaspiromycosis.

Syndromes

Occasionally pneumonia.

A disseminated illness in S. Africa. It can look like a widespread folliculitis (PubMed).  Also a case out of India (PubMed).

Treatment

"Recently, the susceptibility of an isolate of E. crescens to various antifungal agents was determined (5). The MICs (in μg/ml) of amphotericin B, itraconazole, voriconazole, caspofungin, fluconazole, and 5-fluorocytosine were 0.06, 0.12 to 0.25, 0.06, 0.5, 64, and 8, respectively, with no significant differences in susceptibilities between the aleurioconidia and adiaspores. Only amphotericin B was fungicidal (PubMed)".

In one case series, amphotericin treatment was most associated with survival (PubMed).

Notes

Can cause a positive urine histoplasma antigen.