Clonorchis sinensis

Microbiology

Liver fluke. Freshwater snails to fish to fish-eating mammals such as humans, dogs, cats, rats, pigs, badgers, weasels, camels, and buffaloes. Camels eat fish? Who knew?


Epidemiologic Risks

Eating raw fish in Asia. Evidently cases are increasing in China (PubMed).

"Lightly salted, smoked, or pickled fish may contain infectious parasites."


Syndromes

Cholangitis with eosinophilia.

Look for eggs in the stool to diagnose, a bit easier than taking out the gallbladder.

The parasite can live up to 30 years, producing eggs the entire time.


Treatment

Praziquantel 75 mg/kg/day in three doses for 2 days.

Albendazole 10 mg/kg x 7 d may also be used.

400 mg tribendimidine once has fewer side effects and equal efficacy but is only available in China (PubMed).


Notes

It is also lead to hepatobiliary cancer, not the first chronic infection to result in malignancy.

Has been found in Chinese corpses buried in 278 BCE.

Last update: 02/19/21