Infectious Disease Compendium

Calymmatobacterium granulomatis

Microbiology

Gram negative rods that have bipolar staining and look like safety pins. For those of you who only know Velcro, safety pins were once used to hold cloth diapers in place.

Epidemiologic Risks

Having sex in Southeast India, Papua New Guinea, the Caribbean, South America (esp Brazil) and South Africa (each place individually, not all of them at once or sequentially).

Syndromes

AKA Donovaniasis or Granuloma Inguinale. Genital ulcers that are PAINLESS.

Treatment

Doxycycline 100 bid for 3 weeks preferred OR azithromycin 1 gm po q week x 3 OR erythromycin (500 qid x 3 weeks )OR TMP/Sulfa (1 bid for 3 weeks) OR quinolones (cipro 750 bid x 3 weeks)for four weeks or complete healing.

Three weeks is the minimum; continue until all the lesions are gone.

Notes

Can't culture it, diagnosis is made on histopathology.