Infectious Disease Compendium

Klebsiella (Calymmatobacterium) granulomatis


Gram negative rods that have bipolar staining and look like safety pins. For those of you who only know Velcro, safety pins were once used to hold cloth diapers in place.

Epidemiologic Risks

Having sex in Southeast India, Papua New Guinea, the Caribbean, South America (esp Brazil) and South Africa (each place individually, not all of them at once or sequentially).


AKA Donovaniasis or Granuloma Inguinale. Genital ulcers that are PAINLESS.


Doxycycline 100 bid for 3 weeks preferred OR azithromycin 1 gm po q week x 3 OR erythromycin (500 qid x 3 weeks )OR TMP/Sulfa (1 bid for 3 weeks) OR quinolones (cipro 750 bid x 3 weeks)for four weeks or complete healing.

Three weeks is the minimum; continue until all the lesions are gone.


Can't culture it, diagnosis is made on histopathology.

Last update: 05/05/18