Infectious Disease Compendium

Anaplasma

Microbiology

Anaplasma phagocytophilum, Anaplasma ovis, A. marginale, Anaplasma capra (In China (PubMed)). A. phagocytophilia (was Ehrlichia phagocytophilia). In the family of Ehrlichia.

Epidemiologic Risks

A. phagocytophili from black legged tick bites (Ixodes scapularis and Ixodes pacificus) in eastern and western US, also parks in Germany (and probably elsewhere) (PubMed). In the US Minnesota, Wisconsin, and Rhode Island have the highest reported cases.

The actual incidence in the MidWest of the US and Canada is likely under reported.

Syndromes

A. phagocytophilia causes human granulocytic ehrlicheosis. Fevers, myalgias, transaminitis, low WBC. A. capra can have a rash and/or eschar.

A. marginale infects the erythrocytes of cattle.

Treatment

A. marginale, not a human pathogen. Yet. Someday, some poor cowboy will come down with this.

A. phagocytophilia: doxycycline or tetracycline, quinolones may work but haven't been tested.

Notes

In HGE 20 - 80% of patients have Anaplasma morulae in peripheral blood neutrophils, rare in HME.