Infectious Disease Compendium

Adenovirus

Microbiology

Virus.

Epidemiologic Risks

The viruses is spread from person to person by coughing or sneezing. People can become infected by touching something with adenovirus on it and then touching their mouth, nose, or eyes. So I guess those wipes for the shopping cart at the store may be doing something.

Syndromes

Acute respiratory disease and pneumonia (Young adults), coryza, pharyngitis (Infants), disseminated infection (neonates), epidemic keratoconjunctivitis (Adult), pneumonia with dissemination, urinary tract infection (immunocompromised), upper respiratory disease (children), central nervous system disease including encephalitis (Immunocompromised), Diarrhea (children), hemorrhagic cystitis (children), Intestinal infection (immunocompromised), intussusception (children), meningoencephalitis (children), pharyngoconjunctival fever (children).

In the transplant patient, viremia without symptoms is common, it usually progresses in stem cell transplant.

Invasive disease occurs in transplant patients; the worse the transplant immunosuppression, the worse the infection.

PCR is the way to diagnose.

Treatment

Who benefits and when to treat is, as always in the transplant patient, uncertain. Cidofovir is better than ganciclovir; lipid complexed cidofovir may be the way to go in the future. Case reports of success with ribavirin and IVIG but everyone gets ribavirin when they have a severe viral infection but I get the sense it rarely helps.

As of the end of 2017, Brincidofovir (a prodrug of cidofovir) is in the pipeline as a potential treatment.

Notes