Infectious Disease Compendium

Abiotrophia defectiva (aka nutritionally deficient streptococcus)


Gram positive cocci. Some Abiotrophia have been renamed Granulicatella. Just to piss me off. I suspect that microbiologists like to get drunk once a year and rename organisms to annoy clinicians.

It can be difficult to grow in blood cultures; hence the name.

Epidemiologic Risks

Mouth flora.


If you get a positive blood culture, think endocarditis. Is reported to cause the occasional arthritis, meningitis, and prosthetic infection.


Penicillin +/- gentamicin. In vitro susceptibilities in one study (PubMed) were penicillin 8%; amoxicillin 92%; ceftriaxone 3%; meropenem 100%; and 100% for clindamycin, rifampin, levofloxacin, ofloxacin, quinupristin/dalfopristin, and vancomycin. Daptomycin works in vitro (PubMed).


Endocarditis does not respond well to therapy, often has emboli, a ring abscess and valve failure.

The name means life-nutrition-deficiency.

Curious Cases

Relevant links to my Medscape blog

No Other Explanation

Last update: 05/05/18